Quantitative Analysis of Relaxation Rate Dependence on Interecho Time in MagA-expressing, Iron-labeled Cells

Quantitative model for the interecho time dependence of the CPMG relaxation rate in iron-rich gray matter.

A quantitative model is proposed for computing the dependence on the interecho time of the NMR relaxation rate in iron-rich gray matter obtained with a Carr-Purcell-Meiboom-Gill sequence. The model consists of representing oligodendrocytes as identical magnetic spheres arranged in a spatially random pattern, and in approximating water diffusion as isotropic and unrestricted. Predictions of the ...

Biophysical features of MagA expression in mammalian cells: implications for MRI contrast

We compared overexpression of the magnetotactic bacterial gene MagA with the modified mammalian ferritin genes HF + LF, in which both heavy and light subunits lack iron response elements. Whereas both expression systems have been proposed for use in non-invasive, magnetic resonance (MR) reporter gene expression, limited information is available regarding their relative potential for providing g...

Characterization of Maga Expression and Iron Uptake in P19 Cells: Implications for Use as a Gene-Based Contrast Agent

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MRI Relaxation Rates: A Quantitative Approach to Track Tumour Cells Expressing MagA

MS-1 magA

Bacterial genes involved in the biomineralization of magnetic nanoparticles in magnetotactic bacteria have recently been proposed as reporters for magnetic resonance imaging (MRI). In such systems, the expression of the bacterial genes in mammalian cells purportedly leads to greater concentrations of intracellular iron or the biomineralization of iron oxides, thus leading to an enhancement in r...